Organic Process Research & Development

Facile, fast and safe process development of nitration and bromination reactions using continuous flow reactors

J Pelleter, F Renaud

Index: Pelleter, Jacques; Renaud, Fabrice Organic Process Research and Development, 2009 , vol. 13, # 4 p. 698 - 705

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Citation Number: 52

Abstract

Chemists working in a pilot plant often face safety issues during scale-up operations. With the help of emerging microfluidic applications and microdevices, running hazardous, highly exothermic or potentially unstable reactions can be easily transposed into a safe continuous flow mode. This paper describes how a potentially hazardous pyrazole nitration and the bromination of a variety of electron-rich heteroaromatic substrates were efficiently ...