Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione

HW Lee, BY Kim, JB Ahn, SK Kang, JH Lee…

Index: Lee, Hong Woo; Bok, Young Kim; Joong, Bok Ahn; Sung, Kwon Kang; Lee, Jung Hwa; Jae, Soo Shin; Soon, Kil Ahn; Lee, Sang Joon; Seung, Soo Yoon European Journal of Medicinal Chemistry, 2005 , vol. 40, # 9 p. 862 - 874

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Citation Number: 90

Abstract

We previously reported the synthesis and biological activity of novel substituted pyridines and purines having thiazolidinedione with hypoglycemic and hypolipidemic activities. We now report the synthesis and antidiabetic activity of novel substituted pyrimidines having thiazolidinedione moiety. These compounds (entry No. 5a–i, 10a–d and 16) were evaluated for their glucose and lipid lowering activity in KKAy mice. From the results, novel ...