International Journal of Clinical Pharmacology, Therapy and Toxicology 1981-05-01

The effect of food on the absorption of alpha-tocopheryl nicotinate in beagle dogs and human volunteers.

J Hasegawa, Y Tomono, T Fujita, K Sugiyama, K Hamamura

Index: Int. J. Clin. Pharmacol. Ther. Toxicol. 19(5) , 216-9, (1981)

Full Text: HTML

Abstract

The effect of food on absorption of d,1-alpha-tocopheryl nicotinate was studied in cross-over studies with eight beagle dogs and four human volunteers. When 100 mg of alpha-tocopheryl nicotinate in gelatin capsule was administered p.o. to beagle dogs in both a fasted state and after eating, the plasma peak level (Cmax) and area under the curve (AUC) of this ester in nonfasted state was five-fold higher than in fasted state, although the peak time (tmax) did not markedly differ between both conditions. Cmax and AUC after oral administration of 600 mg of alpha-tocopheryl nicotinate in human volunteers in nonfasted state was 32-fold and 29-fold higher, respectively, than during fasted state, without delay in tmax. The plasma levels of this ester following ingestion of 200 mg in fasted state were not detectable. A comparison of the 600-mg with 200-mg dose level during nonfasted state showed the former to be 1.8-fold higher in Cmax and 2.3-fold in AUC.

Related Compounds

  • Vitamin E Nicotin...

Related Articles:

Antiarrhythmic activity of alpha-tocopherol nicotinate and related compounds and their physico-chemical properties.

1987-08-01

[Arzneimittelforschung 37(8) , 920-3, (1987)]

High-performance liquid chromatographic determination of alpha-tocopheryl nicotinate in cosmetic preparations.

[J. Chromatogr. A. 593(1-2) , 95-7, (1992)]

Comparisons between absorption of vitamin E in patients with chronic pancreatitis and healthy controls: the bioavailability of vitamin E.

1986-04-01

[Tohoku J. Exp. Med. 148(4) , 393-401, (1986)]

A nutritional evaluation of vitamin E status in very low birth weight infants with respect to changes in plasma and red blood cell tocopherol levels.

1988-06-01

[J. Nutr. Sci. Vitaminol. 34(3) , 293-307, (1988)]

A family of familial hypercholesterolemia with cerebral infarction and without coronary heart disease. An unusual case with corneal opacity, polyneuropathy and carpal tunnel syndrome in the family: therapy with probucol and tocopherol nicotinate.

1991-11-01

[J. Neurol. Sci. 106(1) , 10-8, (1991)]

More Articles...