Synthesis of homochiral 5-and 8-substituted 2-[((2-(2, 6-dimethoxyphenoxy)-ethyl) amino) methyl]-1, 4-benzodioxanes and electrophoretic determination of their …

…, M Pallavicini, L Villa, D Pezzetta

Index: Valoti; Pallavicini; Villa; Pezzetta Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 1018 - 1025

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Citation Number: 31

Abstract

Among the structures which have the capacity to interact with R1-adrenoceptors, benzodioxanes are one of the main classes. In particular, WB4101, which can be considered the lead compound of such a class, exhibits a nanomolar affinity toward R1- adrenoceptor, the S enantiomer possessing remarkably higher affinity than the R enantiomer. 1 As part of our ongoing program aimed at the study of chiral benzodioxane ...