[Central depressant drugs. 3. 3-Aromatic-aliphatic-substituted 4-hydroxypyrimido-[1,2-a]benzimidazol-2-ones].
A Kreutzberger, M Leger
Index: Arzneimittelforschung 33(11) , 1517-8, (1983)
Full Text: HTML
Abstract
Within the structural class of pyrimidol[1,2-a]benzimidazole-2,4-diones accessible through condensation of 2-amino-benzimidazole (1) with malonates (2) there occur representatives exhibiting centrally dampening properties. In particular, aromatic moieties have now been included into the present investigations. By condensation of 1 with diethyl benzylmalonate (2a), 3-benzyl-4-hydroxypyrimido[1,2-a]benzimidazole-2-one (3a) has been synthesized. In the same manner, 4-hydroxy-3-(2'-phenylethyl)pyrimido-[1,2-a]benzimidazole-2-one (3b) has been prepared from 1 and diethyl (2'-phenylethyl)malonate (2b).
Related Compounds
Related Articles:
Enzymatic asymmetrization of prochiral 2-benzyl-1, 3-propanediol through esterification in solvent media. Ducret A, et al.
[Biotechnol. Lett. 22(8) , 709-713, (2000)]
Dioxygen adducts of nickel (II) and cobalt (II) dioxopentaazamacrocyclic complexes: Kinetics, stabilities, and hydroxylation of the ligands in the nickel dioxygen complexes. Chen D, et al.
[Inorg. Chem. 30(6) , 1396-1402, (1991)]