YAKUGAKU ZASSHI 2003-05-01

[A case in which tofisopam was effective for treatment of paroxysmal supraventricular tachycardia].

Ryuji Kato, Kazuya Ooi, Kazuyuki Ueno

Index: Yakugaku Zasshi 123(5) , 365-8, (2003)

Full Text: HTML

Abstract

Paroxysmal supraventricular tachycardia (PSVT) is a reentrant tachycardia, and the autonomic nervous system influences the paroxysms of PSVT. Tofisopam (Grandaxin) is a derivative of benzodiazepines. It is reported that heart rate variability (HRV) reveals the function of the autonomic nervous system and is used as an index of the effects of the autonomic nervous system on the heart rhythm. In previous studies, it was reported that tofisopam improved HRV. In this case report, the frequency of PSVT was significantly decreased and subjective symptoms of arrhythmia were eliminated after the administration of tofisopam. R-R interval variability and high-frequency power (HF; 0.15-0.40 Hz) were increased, and [low-frequency power (LF; 0.04-0.15 Hz)]/HF was decreased after administration of tofisopam. These results suggest that tofisopam overcame the existing imbalance of the sympathetic and vagus nervous system. In this case report, it is suggested that tofisopam is effective for the treatment of PSVT.

Related Compounds

  • Tofisopam

Related Articles:

The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis.

2010-11-01

[J. Neural Transm. Gen. Sect. 117(11) , 1319-25, (2010)]

[Pineal hormone melatonin in low doses potentiates psychotropic and chronotropic activity of tofisopam in rats].

2013-01-01

[Eksp. Klin. Farmakol. 76(4) , 15-7, (2013)]

Clinical trial: dextofisopam in the treatment of patients with diarrhoea-predominant or alternating irritable bowel syndrome.

2008-01-15

[Aliment. Pharmacol. Ther. 27(2) , 197-206, (2008)]

Various effects of antidepressant drugs on bone microarchitectecture, mechanical properties and bone remodeling.

2007-05-15

[Toxicol. Appl. Pharmacol. 221(1) , 111-8, (2007)]

Method validation and determination of enantiomers and conformers in tofisopam drug substances and drug products by chiral high-performance liquid chromatography and kinetic and thermodynamic study of the interconversion of the conformers.

2006-09-29

[J. Chromatogr. A. 1129(1) , 47-53, (2006)]

More Articles...