Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potency

P Chen, EJ Iwanowicz, D Norris, HH Gu, J Lin…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3153 - 3156

Full Text: HTML

Citation Number: 29

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... As outlined in Scheme 1, two general approaches were taken to prepare the key intermediate, the imidazo[1,5-a]quinoxalin- 4(5H)-one 4, using the chemistry developed in this lab. ...

Related Articles:

… : Synthesis and Structure-Activity Relationships of 7-[3-(Cyclohexylmethyl) ureido]-3-{1-methyl-1H-pyrrolo [2, 3-b] pyridin-3-yl} quinoxalin-2 (1H)-one Derivatives

[Aoki, Katsuyuki; Obata, Tatsuhiro; Yamazaki, Yosuke; Mori, Yoshikazu; Hirokawa, Hiroko; Koseki, Jun-Ichi; Hattori, Tomohisa; Niitsu, Kazuaki; Takeda, Shuichi; Aburada, Masaki; Miyamoto, Ken-Ichi Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 2 p. 255 - 267]

More Articles...