Tetrahedron letters

Sonogashira cross-coupling reaction of 3-iodoindazoles with various terminal alkynes: a mild and flexible strategy to design 2-aza tryptamines

A Arnautu, V Collot, JC Ros, C Alayrac, B Witulski…

Index: Arnautu, Anca; Collot, Valerie; Ros, Javier Calvo; Alayrac, Carole; Witulski, Bernhard; Rault, Sylvain Tetrahedron Letters, 2002 , vol. 43, # 15 p. 2695 - 2697

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Citation Number: 41

Abstract

This paper describes a Sonogashira-type cross-coupling reaction of 3-iodoindazoles with various terminal alkynes as a general route to 3-alkynylindazoles. The coupling reaction is illustrated by the preparation of new indazolylpropiolic or propargylic derivatives. Scope and limitation of the method are outlined.