Pd (PPh 3) 4-catalyzed direct ortho-fluorination of 2-arylbenzothiazoles with an electrophilic fluoride N-fluorobenzenesulfonimide (NFSI)

Q Ding, C Ye, S Pu, B Cao

Index: Ding, Qiuping; Ye, Changqing; Pu, Shouzhi; Cao, Banpeng Tetrahedron, 2014 , vol. 70, # 2 p. 409 - 416

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Citation Number: 22

Abstract

Abstract An efficient protocol was developed for regio-selective Pd-catalyzed direct ortho- fluorination of 2-arylbenzo [d] thiazoles using N-fluorobenzenesulfonimide (NFSI) as the F+ source, and l-proline as the crucial promoter. The present method offered a practical route to synthesize valuable fluorinated products, which are of potential importance in the pharmaceutical and agrochemical industries.