Journal of Natural Medicines 2011-01-01

2-methoxy-1,4-naphthoquinone isolated from Impatiens balsamina in a screening program for activity to inhibit Wnt signaling.

Naomi Mori, Kazufumi Toume, Midori A Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

Index: J. Nat. Med. 65(1) , 234-6, (2011)

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Abstract

A screening study using a luciferase assay to identify natural products which inhibit Wnt signaling was carried out. The bioassay-guided fractionation of aerial parts of a plant, Impatiens balsamina, led to the isolation of 2-methoxy-1,4-naphthoquinone (1) as an active compound. Compound 1 inhibited the TCF/β-catenin (TOP) transcriptional activity (IC(50) 2.9 µM), while it decreased the transcriptional activity of FOP (mutated TCF-binding site)-transfected cells at >5 µM.

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