A Highly Selective, High??Speed, and Hydrolysis??Free O??Acylation in Subcritical Water in the Absence of a Catalyst

M Sato, K Matsushima, H Kawanami…

Index: Sato, Masahiro; Matsushima, Keiichiro; Kawanami, Hajime; Ikuhsima, Yutaka Angewandte Chemie - International Edition, 2007 , vol. 46, # 33 p. 6284 - 6288

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Citation Number: 23

Abstract

The acylation of alcohols and phenols to esters with carboxylic anhydrides is a fundamental chemical transformation in the production of important intermediates and fine chemicals.[1] Catalytic versions of this reaction are being investigated intensively to replace the current non-stoichiometric acylation processes that generate large amounts of carboxylic acid and solvent waste.[2–8] Lewis acids such as Sc (OTf) 3,[4] Me3SiOTf,[5] and In (OTf) 3 [6] have ...