Molecules 2012-01-01

Synthesis and bioactivity of pyrazole acyl thiourea derivatives.

Jian Wu, Qing Shi, Zhuo Chen, Ming He, Linhong Jin, Deyu Hu

Index: Molecules 17(5) , 5139-50, (2012)

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Abstract

Sixteen novel pyrazole acyl thiourea derivatives 6 were synthesized from monomethylhydrazine (phenylhydrazine) and ethyl acetoacetate. The key 5-chloro-3-methyl-1-substituted-1H-pyrazole-4-carbonyl chloride intermediates 4 were first generated in four steps through cyclization, formylation, oxidation and acylation. Thess were then reacted with ammonium thiocyanate in the presence of PEG-400 to afford 5-chloro-3-methyl-1-substituted-1H-pyrazole-4-carbonyl isothiocyanates 5. Subsequent reaction with fluorinated aromatic amines resulted in the formation of the title compounds. The synthesized compound were unequivocally characterized by IR, ¹H-NMR, ¹³C-NMR and elemental analysis and some of the synthesized compounds displayed good antifungal activities against Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica and anti-TMV activity in preliminary antifungal activity tests.

Related Compounds

  • Ammonium thiocyana...
  • Ethyl acetoacetate
  • Phenylhydrazine
  • Phenylhydrazine hy...

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