Human & Experimental Toxicology 1991-01-01

Oral pharmacokinetics of fluazifop-butyl in human volunteers.

B H Woollen, T B Hart, P L Batten, W J Laird, D S Davies, C T Dollery

Index: Hum. Exp. Toxicol. 10(1) , 39-43, (1991)

Full Text: HTML

Abstract

1. Fluazifop-butyl, the active ingredient of FUSILADE, a selective herbicide, was administered orally to three male volunteers at a dose level of 0.07 mg kg-1 body weight. Over a period of 6 d between 80 and 93% of the dose was excreted in urine as the metabolite fluazifop, the majority within the first 24 h. Peak plasma concentrations of fluazifop occurred 1-2.5 h after administration. 2. The elimination of fluazifop from plasma and urine can be described by a one-compartment pharmacokinetic model and the elimination half-life was estimated from blood and urine data to be within the range 9-37 h. Fluazifop was found to bind to serum proteins. 3. The study indicates that the amount of fluazifop-butyl absorbed in exposed persons can be assessed by measuring fluazifop concentrations in urine.

Related Compounds

  • fluazifop
  • fluazifop-P-butyl
  • Propanoic acid,2-[...

Related Articles:

Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum.

2007-01-01

[Antimicrob. Agents Chemother. 51 , 307-16, (2007)]

Trypanosoma brucei: inhibition of acetyl-CoA carboxylase by haloxyfop.

2012-02-01

[Exp. Parasitol. 130(2) , 159-65, (2012)]

Characterisation of target-site resistance to ACCase-inhibiting herbicides in the weed Alopecurus myosuroides (black-grass).

2003-02-01

[Pest Manag. Sci. 59(2) , 190-201, (2003)]

Differential sensitivity of lipid metabolism in monocotyledons to grass-specific herbicides.

1993-05-01

[Biochem. Soc. Trans. 21(2) , 183S, (1993)]

Acetyl-CoA carboxylase exerts strong flux control over lipid synthesis in plants.

1994-01-20

[Biochim. Biophys. Acta 1210(3) , 369-72, (1994)]

More Articles...