Analyst (Cambridge UK) 1991-12-01

Determination of 4-methyl-cis-hexahydrophthalic anhydride in human blood by gas chromatography with electron-capture detection.

P Pfäffli, H Savolainen

Index: Analyst 116(12) , 1333-6, (1991)

Full Text: HTML

Abstract

A gas-chromatographic technique using 63Ni electron-capture detection was applied to the determination of 4-methyl-cis-hexahydrophthalic anhydride in the blood of workers occupationally exposed to this airborne agent. The detection limit was 0.24 nmol ml-1. For occupational exposure to between 0.14 and 0.31 mg m-3 of the anhydride, the anhydride concentration in the workers' blood samples ranged from 3.4 to 10.7 nmol ml-1. The results are consistent with earlier findings in animal exposure experiments and support the view that the hydrolysis of the anhydride in a biological medium is not spontaneous, but might be an enzyme-catalysed reaction. The resulting dicarboxylic acid is excreted by the kidneys without further conjugation reactions.

Related Compounds

  • Hexahydro-4-methyl...

Related Articles:

Delayed and immediate allergy caused by methylhexahydrophthalic anhydride.

1997-01-01

[Contact Dermatitis 36(1) , 34-8, (1997)]

Determination of hexahydrophthalic acid and methylhexahydrophthalic acid in plasma after derivatisation with pentafluorobenzyl bromide using gas chromatography and mass spectrometric detection.

1997-04-11

[J. Chromatogr. B. Biomed. Sci. Appl. 691(2) , 331-9, (1997)]

Human hemoglobin adducts following exposure to hexahydrophthalic anhydride and methylhexahydrophthalic anhydride.

1998-12-01

[Toxicol. Appl. Pharmacol. 153(2) , 152-60, (1998)]

Mass spectrometric characterization of human hemoglobin adducts formed in vitro by hexahydrophthalic anhydride.

2002-04-01

[Chem. Res. Toxicol. 15(4) , 562-9, (2002)]

Biological monitoring of methylhexahydrophthalic anhydride by determination of methylhexahydrophthalic acid in urine and plasma from exposed workers.

1997-01-01

[Int. Arch. Occup. Environ. Health 70(2) , 128-32, (1997)]

More Articles...