European Journal of Pharmacology 1983-08-19

Antagonism of the discriminative effects of diazepam by pyrazoloquinolines in rats.

H E Shannon, S Herling

Index: Eur. J. Pharmacol. 92(1-2) , 155-7, (1983)

Full Text: HTML

Abstract

The diazepam-like agonist and diazepam antagonist properties of the pyrazoloquinoline benzodiazepine receptor ligands CGS8216, CGS9895 and CGS9896 were evaluated in rats trained to discriminate between saline and 1.0 mg/kg of diazepam in a two-choice, discrete-trial procedure. None of the three pyrazoloquinolines produced diazepam-like discriminative effects over the dose range of 1.0-30 mg/kg. The effects of 1.0 mg/kg of diazepam were antagonized by CGS8216 and CGS9895, but not by CGS9896. The present results provide behavioral evidence for benzodiazepine receptor heterogeneity.

Related Compounds

  • CGS-9895

Related Articles:

Benzodiazepine receptor ligands modulate ethanol drinking in alcohol-preferring rats.

1994-09-22

[Eur. J. Pharmacol. 263(1-2) , 141-7, (1994)]

Comparison of a new class of pyrrole containing benzodiazepine ligands to the pyrazoloquinolinones CGS 9896, 9895, and 8216.

1994-01-01

[Med. Chem. Res. 4(5) , 307-14, (1994)]

Benzodiazepine-induced hyperphagia: stereospecificity and antagonism by pyrazoloquinolines, CGS 9895 and CGS 9896.

1986-01-01

[Psychopharmacology 89(4) , 462-6, (1986)]

Differential diazepam-antagonist effects of the benzodiazepine receptor ligand CGS 9895 in rodents.

1985-12-01

[J. Pharmacol. Exp. Ther. 235(3) , 589-95, (1985)]

Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions.

1987-01-01

[Physiol. Behav. 41(3) , 241-5, (1987)]

More Articles...