Generation and reaction of cyano-substituted aryllithium compounds using microreactors

…, H Kim, H Usutani, C Matsuo, J Yoshida

Index: Nagaki, Aiichiro; Kim, Heejin; Usutani, Hirotsugu; Matsuo, Chika; Yoshida, Jun-Ichi Organic and Biomolecular Chemistry, 2010 , vol. 8, # 5 p. 1212 - 1217

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Citation Number: 50

Abstract

We developed a microflow method for the generation and reactions of aryllithiums bearing a cyano group, including o-lithiobenzonitrile, m-lithiobenzonitrile and p-lithiobenzonitrile. The method was effective at much higher temperatures than are required for conventional macrobatch reactions, by virtue of rapid mixing, short residence time, and efficient temperature control. In addition, reactions of o-lithiobenzonitrile with carbonyl compounds ...

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