Organic letters

Rhodium complex-catalyzed reaction of isonitriles with carbonyl compounds: Catalytic synthesis of pyrroles

H Takaya, S Kojima, SI Murahashi

Index: Takaya, Hikaru; Kojima, Sachiko; Murahashi, Shun-Ichi Organic Letters, 2001 , vol. 3, # 3 p. 421 - 424

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Citation Number: 93

Abstract

Low-valent rhodium complexes are efficient catalysts for the activation of α-CH bond of isonitriles. Addition of isonitriles to carbonyl compounds proceeds under mild and neutral conditions to give the corresponding α, β-unsaturated formamides. Catalytic synthesis of pyrroles can be performed by cyclocondensation of isonitriles with 1, 3-dicarbonyl compounds.