Scale-up synthesis of a TRPV1 antagonist featuring a facile thiazolo [5, 4-d] pyrimidine formation

J Liu, AE Fitzgerald, AD Lebsack…

Index: Organic Process Research and Development, , vol. 15, # 2 p. 382 - 388

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Citation Number: 5

Abstract

... Organic Process Research & Development. ... byproducts (DMA, 2-propanol, HCl, and isopropyl carbamimidate) were water soluble, we developed a simple procedure to isolate ... 17, 20, and 19 could be monitored by HPLC, which enabled convenient and precise in-process control ...