Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3, 5-dimethylbenzyl) uracil derivatives

…, J Balzarini, R Snoecks, G Andrei, E De Clercq

Index: Maruyama, Tokumi; Kozai, Shigetada; Demizu, Yosuke; Witvrouw, Myriam; Pannecouque, Christophe; Balzarini, Jan; Snoecks, Robert; Andrei, Graciella; De Clercq, Erik Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 3 p. 325 - 333

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Citation Number: 33

Abstract

3-(3, 5-Dimethylbenzyl) uracil (3) was treated with alkyl halides in the presence of alkali to give 1-substituted congeners. Condensation of 3 with alcohols using the Mitsunobu reaction was also employed as an alternative method. The anti-HIV-1 activity of 1-substituted analogues of 3-(3, 5-dimethylbenzyl) uracil was evaluated according to previously established procedures. It appeared that the nitrogen of the 1-cyanomethyl group is ...