Facile preparation of beta-fluoro amines by the reaction of aziridines with potassium fluoride dihydrate in the presence of Bu4NHSO4.
Ren-Hua Fan, Yong-Gui Zhou, Wan-Xuan Zhang, Xue-Long Hou, Li-Xin Dai
Index: J. Org. Chem. 69(2) , 335-8, (2004)
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Abstract
Potassium fluoride combined with tetrabutylammonium bisulfate is an efficient reagent to convert a variety of aziridines derived from cyclic and acyclic alkenes to beta-fluoro amine derivatives in high yield.
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