Synthesis and Antibacterial Activity of Symmetrical Bis-quaternaries Derived from β-Ionone and Related Compounds

S Teitel, P Heck, E Grunberg…

Index: Teitel,S. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, p. 780 - 787

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Abstract

I CH, were prepared from the corresponding primary or secondary amines, or secondary diamines, by monoor dimethylation using formic acid-formaldehyde, accordiiig to the procedure of Eschweiler-ClarkeY (method B). The intermediate primary and secondary monoamines were obtained by reductive condensation of an aldehyde or ketone with ammonia or a primary amine in the presence of Raiiey nickel catalyst (method A). When a, ...