Metabolites of ebrotidine, a new H2??receptor antagonist, in human urine

E Rozman, MT Galcerán, L Anglada…

Index: Rozman; Galceran; Anglada; Albet Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 2 p. 252 - 254

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Citation Number: 8

Abstract

Abstract Ebrotidine is a new H 2-receptor antagonist which exhibits a remarkable ability for gastric mucosal protection. A preliminary metabolic pathway for this compound was proposed and the hypothetic metabolites were synthesized. The presence of ebrotidine and its metabolites ebrotidine S-oxide and 4-bromobenzenesulfonamide in human urine has been confirmed by HPLC separation and spectroscopic characterization of the collected ...

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