4-(Diphenylmethyl)-1-(iminomethyl) piperidines as gastric antisecretory agents

MK Scott, HI Jacoby, JE Mills, AC Bonfilio…

Index: Scott; Jacoby; Mills; Bonfilio; Rasmussen Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 535 - 538

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Citation Number: 22

Abstract

4-(Diphenylmethyl)-l-piperidinemethanimine (1) is a potent oral gastric antisecretory agent in rats but contains a strong anticholinergic component. Since a nonanticholinergic gastric antisecretory drug would be useful in the treatment of peptic ulcer disease, a program was initiated by us to find such an agent based on 1. Compound 1 contains structural elements common to the anticholinergics atropine and homatropine. Studies on the structureactivity ...