American Journal of Physiology - Gastrointestinal and Liver Physiology 2002-04-01

Putative effect of Helicobacter pylori and gastritis on gastric acid secretion in cat.

Iradj Sobhani, Sergio Canedo, Beatriz Alchepo, Christiane Vissuzaine, Catherine Chevalier, Marion Buyse, Laurent Moizo, J Pierre Laigneau, Michel Mignon, J Miguel Lewin, André Bado

Index: Am. J. Physiol. Gastrointest. Liver Physiol. 282(4) , G727-34, (2002)

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Abstract

Helicobacter pylori may increase or inhibit gastric acid. We studied acid variations and plasma gastrin in cats harboring Helicobacter felis, harboring H. pylori, or free of gastric pathogens with reference to thioperamide (H(3) receptor antagonist) and SR-27417A (PAF receptor antagonist). In cats harboring H. felis, gastric mucosa were histologically normal. After H. felis eradication, pentagastrin-stimulated acid secretion was increased (40%) compared with the situation before eradication. Thioperamide abolished this inhibitory effect of H. felis, whereas SR-27417A did not. Basal and meal-stimulated plasma gastrin levels were not affected by eradication therapy. Acid secretion was inhibited (-80%) in week 3, increased from weeks 5 to 9, and remained constant for up to 42 weeks after H. pylori infection. SR-27417A had no effect on acid secretion before week 8 but inhibited it thereafter, and thioperamide increased it (20%) only before week 7 in those cats. Helicobacter inhibits gastric acid via an H(3) receptor pathway. Inflammatory mediators are thus involved in adaptation to the inhibitory effects of H. pylori on acid secretion.

Related Compounds

  • Foropafant

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