Synthesis and anti-inflammatory, analgesic, ulcerogenic, and cyclooxygenase activities of novel quinazolinyl-Δ 2-pyrazolines

…, S Sharma, K Bajaj, D Bansal, S Sharma…

Index: Kumar, Ashok; Sharma, Shalabh; Bajaj, Kiran; Bansal, Deepti; Sharma, Shipra; Saxena, Archana K. K.; Lata; Gupta; Srivastava Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 8 p. 1979 - 1984

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Citation Number: 36

Abstract

Abstract: Synthesis of 2-(ω-chloroacetonyl)-3-substituted-phenyl-6-halo/6, 8- dihaloquinazolin-4 (3H)-ones 6-10, 2-(ω-hydrazinoacetonyl)-3-substituted-phenyl-6-halo/6, 8-dihaloquinazolin-4 (3H) ones 11-15 and 1'-[3H-3-substituted-phenyl-4-oxo-6-halo/6, 8- dihaloquinazolin-2-acetonyl]-3׳-aryl-5'-(2-substituted-indol-3-yl)-Δ 2-pyrazolines 16-30 have been described. All the compounds have been tested in vivo for their anti-inflammatory, ...

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