Xenobiotica 1980-04-01

The metabolic fate of nitromide in the rat. I. Metabolism and excretion.

V Facchini, L A Griffiths

Index: Xenobiotica 10(4) , 289-97, (1980)

Full Text: HTML

Abstract

1. Following oral administration of nitromide (3,5-dinitrobenzamide) to rats, 67.9% of the dose was excreted in urine and 32.6% in the faeces in 96 h. Significant biliary excretion of nitromide metabolites also occurred, although no evidence of enterohepatic cycling was obtained. Direct secretion of nitromide metabolites into the gastro-intestinal lumen via the mucosa was detected in surgically modified rats. 2. Six faecal, six urinary and three biliary metabolites, all of which were in a reduced form (as monoamines, diamines and their conjugates) were detected following oral administration. 3. The blood of these animals contained reduced metabolites only, as early as 1 h after oral or intraperitoneal administration of nitromide.

Related Compounds

  • Nitromide

Related Articles:

Highly sensitive voltammetric sensor based on catechol-derivative-multiwall carbon nanotubes for the catalytic determination of captopril in patient human urine samples.

2011-10-15

[Colloids Surf. B Biointerfaces 87(2) , 480-8, (2011)]

Preparative enantioseparation of (+/-)-N-(3,4-cis-3-decyl-1,2,3,4-tetrahydrophenanthren-4-yl)-3,5-dinitrobenzamide by centrifugal partition chromatography.

2010-02-19

[J. Chromatogr. A. 1217(8) , 1183-90, (2010)]

Metabolism of nitromide in the rat. II. Sites of nitro-reduction.

1980-04-01

[Xenobiotica 10(4) , 299-305, (1980)]

Identification of the major urinary and fecal metabolites of 3,5-dinitrobenzamide in chickens and rats.

1999-04-01

[Chemosphere 38(8) , 1757-62, (1999)]

More Articles...