Obstetrics and Gynecology Clinics of North America 2012-12-01

Polycystic ovarian syndrome management options.

G Wright Bates, Anthony M Propst

Index: Obstet. Gynecol. Clin. North Am. 39(4) , 495-506, (2012)

Full Text: HTML

Abstract

Polycystic ovarian syndrome (PCOS) is a disorder of androgen excess and ovarian dysfunction. Hirsutism and elevated free testosterone levels are the most consistent signs of the androgen excess. Irregular, infrequent, or absent menses and infertility are symptoms of ovulatory dysfunction. Obesity is also a feature of this syndrome and contributes to associated metabolic abnormalities. Lifestyle modification should be the first treatment and is effective in reducing the signs and symptoms. The ovulatory infertility associated with PCOS can be overcome in most cases with oral (clomiphene citrate or letrozole) or injectable (gonadotropins) agents. Surgical intervention is reserved for cases resistant to medical management.Copyright © 2012 Elsevier Inc. All rights reserved.

Related Compounds

  • Letrozole
  • Clomiphene Citrat...

Related Articles:

Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.

2015-01-01

[Carcinogenesis 36(1) , 122-32, (2015)]

Hypogonadism Associated with Cyp19a1 (Aromatase) Posttranscriptional Upregulation in Celf1 Knockout Mice.

2015-09-01

[Mol. Cell. Biol. 35 , 3244-53, (2015)]

Aromatase (Cyp19a1b) in the pituitary is dynamically involved in the upregulation of lhb but not fshb in the vitellogenic female ricefield eel Monopterus albus.

2014-11-01

[Endocrinology 155(11) , 4531-41, (2014)]

Aurora kinase A and B as new treatment targets in aromatase inhibitor-resistant breast cancer cells.

2015-02-01

[Breast Cancer Res. Treat. 149(3) , 715-26, (2015)]

Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus.

2015-01-01

[Drug Des. Devel. Ther. 9 , 5019-31, (2015)]

More Articles...