Green Chemistry

An economically and environmentally sustainable synthesis of 2-aminobenzothiazoles and 2-aminobenzoxazoles promoted by water

X Zhang, X Jia, J Wang, X Fan

Index: Zhang, Xinying; Jia, Xuefei; Wang, Jianji; Fan, Xuesen Green Chemistry, 2011 , vol. 13, # 2 p. 413 - 418

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Citation Number: 30

Abstract

Tandem reactions of isothiocyanates (1) with 2-aminothiophenols (2), or isothiocyanates (1) with 2-aminophenols (4), were carried out rapidly and efficiently in water. A significant rate acceleration of the reaction between 1a and 2a in water compared with commonly used volatile organic solvents was observed. Through these reactions, a variety of structurally and pharmaceutically interesting 2-aminobenzothiazoles (3) and 2-aminobenzoxazoles (5) ...

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