Journal of Pharmacy and Pharmacology 1998-03-01

The non-peptide neuroprotective agents SR 57746A interacts with neurotrophin 3 to induce differentiation in the PC12 cell-line.

J Fournier, G Boutot, P E Keane, J P Maffrand, G Le Fur, P Soubrié

Index: J. Pharm. Pharmacol. 50(3) , 323-7, (1998)

Full Text: HTML

Abstract

SR 57746A (1-(2beta-naphthylethyl)-4-(3-trifluoromethylphenyl)-1,2,5,6 -tetrahydropyridine hydrochloride) is a neuroprotective compound which potentiates nerve-growth factor (NGF)-induced differentiation in PC12 cells. We have evaluated the interaction of SR 57746A with the other members of the neurotrophin family in this cell-line. In contrast with NGF, neurotrophin-3 did not increase the differentiation of PC12 cells. However, the association of SR 57746A with neurotrophin-3 significantly increased neurite outgrowth. No significant activity on neurite outgrowth was observed with brain-derived neurotrophic factor or neurotrophin-4, either alone or combined with SR 57746A. These results indicate that as well as potentiating the effect of NGF SR 57746A enables neurotrophin-3, which alone is inactive, to increase the differentiation of these cells.

Related Compounds

  • Xaliproden hydroch...

Related Articles:

5-HT1A receptors are involved in the effects of xaliproden on G-protein activation, neurotransmitter release and nociception.

2009-09-01

[Br. J. Pharmacol. 158(1) , 232-42, (2009)]

Magnetic resonance imaging of the neuroprotective effect of xaliproden in rats.

2002-06-01

[Invest. Radiol. 37(6) , 321-7, (2002)]

The neuroprotective agent SR 57746A abrogates experimental autoimmune encephalomyelitis and impairs associated blood-brain barrier disruption: implications for multiple sclerosis treatment.

1999-10-26

[Proc. Natl. Acad. Sci. U. S. A. 96(22) , 12855-9, (1999)]

SR57746A: a survival factor for motor neurons in vivo.

1998-10-01

[J. Neurol. Sci. 160 Suppl 1 , S92-6, (1998)]

Administration of amyloid beta-peptides in the rat medial septum causes memory deficits: reversal by SR 57746A, a non-peptide neurotrophic compound.

1996-08-02

[Neurosci. Lett. 213(2) , 79-82, (1996)]

More Articles...