The Tohoku Journal of Experimental Medicine 1984-11-01

Effects of drug-induced reduction in oxyhemoglobin affinity on survival time of mice in severe hypoxic conditions.

T Kugimiya, K Suwa, Y Inada, K Mayuzumi, T Kasama

Index: Tohoku J. Exp. Med. 144(3) , 315-20, (1984)

Full Text: HTML

Abstract

We studied the effect of ortho-iodo sodium benzoate (OISB) given intraperitoneally to mice. 300 and 600 mg/kg of OISB increased P50 from the control value of 41.2 mmHg to 42.7 mmHg and 45.7 mmHg, respectively. The mice were then exposed to two experimental hypoxias, namely, hypobaric hypoxia and carbon monoxide hypoxia. Mean survival time was prolonged from 67.8 (control saline) to 94.8 sec (OISB 300 mg/kg) and 112.2 sec (OISB 600 mg/kg) in the hypobaric hypoxia, and from 201.3 sec (control saline) to 329.7 sec (OISB 300 mg/kg) and 407.7 sec (OISB 600 mg/kg) in the carbon monoxide hypoxia. We concluded that OISB had prolonged survival time by reducing oxyhemoglobin affinity, thus facilitating oxygen release in severe hypoxic conditions.

Related Compounds

  • 2-Iodobenzoic acid

Related Articles:

Polyamine Triglycerides: Synthesis and Study of Their Potential in Lubrication, Neutralization, and Sequestration.

2015-07-22

[J. Agric. Food Chem. 63 , 6422-9, (2015)]

Structure and function of L-lactate dehydrogenases from thermophilic and mesophilic bacteria. III) The primary structure of thermophilic lactate dehydrogenase from Bacillus stearothermophilus. Hydroxylamine-, o-iodosobenzoic acid- and tryptic-fragments. The complete amino-acid sequence.

1983-07-01

[Hoppe. Seylers. Z. Physiol. Chem. 364(7) , 893-909, (1983)]

One-pot multicomponent synthesis of indoles from 2-iodobenzoic acid.

2008-01-01

[Angew. Chem. Int. Ed. Engl. 47(2) , 350-2, (2008)]

[The efect of ionizing radiation and fasting on the excretion of o-iodobenzoic acid 125I and its conjugates in the urine of rats protected by radioprotective agents].

1983-01-01

[Sb. Ved. Pr. Lek. Fak. Karlovy Univerzity Hradci Kralove. Suppl. 26(3) , 201-15, (1983)]

[The effect of various doses of ionizing radiation on the excretion of o-iodobenzoic acid-125I and their conjugates in the urine of rats].

1979-01-01

[Sb. Ved. Pr. Lek. Fak. Karlovy Univerzity Hradci Kralove. Suppl. 22(2) , 287-98, (1979)]

More Articles...