Journal of Pharmacological Sciences (Print Edition) 2008-01-01

Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects.

Eun-Joo Shin, Phil Ho Lee, Hyun Ji Kim, Toshitaka Nabeshima, Hyoung-Chun Kim

Index: J. Pharmacol. Sci. 106(1) , 22-7, (2008)

Full Text: HTML

Abstract

Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects. Accumulating evidence suggests that metabolism to phencyclidine-like dextrorphan is not essential for the neuroprotective activity of dextromethorphan. Here, we review the neuroprotective properties of dextromethorphan and its potential for abuse and the potential neuroprotective effects of the drug's analogs and 3-hydroxymorphinan, a metabolite of dextromethorphan. These compounds may provide a novel therapeutic direction for the treatment of neurodegenerative diseases such as convulsive or parkinsonian-like disorders.

Related Compounds

  • (+)-3-HYDROXYM...

Related Articles:

A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study.

2009-11-01

[Biomed. Chromatogr. 23(11) , 1131-7, (2009)]

Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry.

2011-01-25

[J. Pharm. Biomed. Anal. 54(2) , 387-94, (2011)]

Validation of a liquid chromatography-mass spectrometry method to assess the metabolism of dextromethorphan in rat everted gut sacs.

2005-05-05

[J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 819(1) , 105-13, (2005)]

New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice.

2003-03-07

[Life Sci. 72(16) , 1883-95, (2003)]

Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism.

2009-02-01

[J. Pharm. Sci. 98(2) , 763-71, (2009)]

More Articles...