Chemoenzymatic method of 1, 2, 4-triazole nucleoside synthesis: possibilities and limitations

ID Konstantinova, MV Chudinov, IV Fateev…

Index: Konstantinova; Chudinov; Fateev; Matveev; Zhurilo; Shvets; Miroshnikov Russian Journal of Bioorganic Chemistry, 2013 , vol. 39, # 1 p. 53 - 71 Bioorganicheskaya Khimiya, 2013 , vol. 39, # 1 p. 61 - 80,20

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Citation Number: 3

Abstract

Abstract Possibilities and limitations of chemoenzymatic synthesis of novel structural analogues of an antiviral preparation of Ribavirin (1-β-D-ribofuranosyl-1, 2, 4-triazole-3- carboxamide) were established. A synthesis of various amides of 1 H-1, 2, 4-triazole-3- carboxylic acid and its 5-substituted analogues—potential substrates of purine nucleoside phosphorylase—has been described. Comparative efficiency of preparation methods of ...