Experimental Cell Research 1998-03-15

A putative G-protein-coupled receptor, H218, is down-regulated during the retinoic acid-induced differentiation of F9 embryonal carcinoma cells.

Y Li, A J MacLennan, M B Rogers

Index: Exp. Cell Res. 239(2) , 320-5, (1998)

Full Text: HTML

Abstract

We have previously cloned a novel guanine nucleotide-binding protein (G-protein)-coupled receptor, H218, that has sequence similarity to a lysophosphatidic acid receptor, edg2. We present here Northern analysis indicating that the H218 mRNA is expressed in undifferentiated F9 embryonal carcinoma cells. The H218 message is down-regulated and its stability is decreased during retinoic acid- and dibutyryl cAMP-induced differentiation. Treatment by various receptor-selective retinoids indicated that retinoic acid receptor beta or gamma signaling, but not retinoid X receptor activation, is required for the down-regulation of H218 mRNA. Activation of the H218 receptor may contribute to the phenotype of undifferentiated F9 embryonal carcinoma cells.

Related Compounds

  • Ro 41-5253

Related Articles:

Effect of all-trans-retinoic acid on enterovirus 71 infection in vitro.

2014-05-01

[Br. J. Nutr. 111(9) , 1586-93, (2014)]

Retinoic acid inhibits in vivo interleukin-2 gene expression and T-cell activation in mice.

2009-04-01

[Immunology 126(4) , 514-22, (2009)]

Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist.

2002-06-01

[Exp. Lung Res. 28(4) , 315-32, (2002)]

Retinoic acid signaling is necessary for the development of the organ of Corti.

1999-09-01

[Dev. Biol. 213(1) , 180-93, (1999)]

Retinoids and human breast cancer: in vivo effects of an antagonist for RAR-alpha.

2005-02-28

[Cancer Lett. 219(1) , 27-31, (2005)]

More Articles...