Aryloxypyrazines as highly selective antagonists of Oxytocin

…, D Ellis, D Pearce, M Ralph, N Sciammetta

Index: Brown, Alan; Ellis, Dave; Pearce, David; Ralph, Michael; Sciammetta, Nunzio Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 10 p. 2634 - 2636

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Citation Number: 4

Abstract

A series of aryloxypyrazines were designed based on structural overlap with previously reported arylpyrazine Oxytocin antagonists. Similarly high levels of Oxytocin antagonism were achievable in this new series. In addition, significant improvements in selectivity over the related vasopressin V1A receptor were also possible.