Molecular Diversity 2011-08-01

New one-pot synthesis of spiro[furo[2,3-d]pyrimidine-6,5'-pyrimidine]pentaones and their sulfur analogues.

Mohammad Jalilzadeh, Nader Noroozi Pesyan, Fereshteh Rezaee, Saeed Rastgar, Yaser Hosseini, Ertan Sahin

Index: Mol. Divers. 15(3) , 721-31, (2011)

Full Text: HTML

Abstract

Reaction of barbituric acid (BA), 1,3-dimethyl barbituric acid (DMBA) and 2-thiobarbituric acid (TBA) with cyanogen bromide and various aldehydes in presence of triethylamine afforded a new class of heterocyclic stable 5-alkyl and/or 5-aryl-1H, 1'H-spiro[furo[2,3-d]pyrimidine-6,5'-pyrimidine]2,2',4,4',6'(3H,3'H,5H)-pentaones which are dimeric forms of barbiturate (uracil and thiouracil derivatives) at 0 °C to ambient temperatures. Structure elucidation is proved by X-ray crystallography, (1)H NMR, (13)C NMR, FT-IR, CHN and mass analyses techniques. Mechanisms of the formations are discussed.

Related Compounds

  • sodium barbiturate
  • Cyanogen bromide

Related Articles:

Identification and characterization of Clostridium perfringens beta toxin variants with differing trypsin sensitivity and in vitro cytotoxicity activity.

2015-04-01

[Infect. Immun. 83(4) , 1477-86, (2015)]

Characterization of two long-chain fatty acid CoA ligases in the Gram-positive bacterium Geobacillus thermodenitrificans NG80-2.

2012-12-20

[Microbiol. Res. 167(10) , 602-7, (2012)]

Synergistic effects of Clostridium perfringens enterotoxin and beta toxin in rabbit small intestinal loops.

2014-07-01

[Infect. Immun. 82(7) , 2958-70, (2014)]

Complementary hydrogen bonding of a carboxylato-barbiturate with urea and acetamide: experimental and theoretical approach.

2011-12-01

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 83(1) , 532-9, (2011)]

Synthesis of 5-alkylated barbituric acids and 3-alkylated indoles via microwave-assisted three-component reactions in solvent-free conditions using Hantzsch 1,4-dihydropyridines as reducing agents.

2012-05-01

[Mol. Divers. 16(2) , 291-8, (2012)]

More Articles...