Chemical & Pharmaceutical Bulletin 2010-04-01

Chromeno[2,3-d]pyrimidine-triones synthesis by a three-component coupling reaction.

Ramin Ghahremanzadeh, Fatemeh Fereshtehnejad, Ayoob Bazgir

Index: Chem. Pharm. Bull. 58(4) , 516-20, (2010)

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Abstract

A simple and one-pot synthesis of new chromeno[2,3-d]pyrimidine-triones by a three-component condensation reaction of barbituric acids, aldehydes and cyclohexane-1,3-diones in refluxing ethanol in the presence of p-toluenesulfonic acid (p-TSA) for 3-10 h is reported. Two cyclohexane-1,3-diones, four barbituric acids and six substituted aldehydes were chosen for the library validation. Prominent among the advantages of this new method are operational simplicity, good yields and easy work-up procedures employed.

Related Compounds

  • sodium barbiturate
  • 1,3-Cyclohexanedio...

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