Bioorganic & Medicinal Chemistry 2008-01-01

Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-α and IL-6 inhibitors

Sandip B. Bharate, Tushar R. Mahajan, Yogesh R. Gole, Mahesh Nambiar, T.T. Matan, Asha Kulkarni-Almeida, Sarala Balachandran, H. Junjappa, Arun Balakrishnan, Ram A. Vishwakarma

Index: Bioorg. Med. Chem. 16 , 7167-76, (2008)

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Abstract

Three different series of pyrazolo[3,4- b]pyridines were synthesized and evaluated for their anti-inflammatory activity against TNF-α and IL-6. Several compounds showed promising IL-6 inhibitory activity, amongst which most potent analogue has IC 50 0.16 μM and is not cytotoxic (IC 50 >100 μM).

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