Cycloalkanones. 8. Hypocholesterolemic activity of long-chain ketones related to pentadecanone

SD Wyrick, IH Hall, C Piantadosi…

Index: Wyrick; Hall; Piantadosi; Fenske Journal of Medicinal Chemistry, 1976 , vol. 19, # 2 p. 219 - 222

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Citation Number: 4

Abstract

Aliphatic analogs of 2, 8-dibenzylcyclooctanone which includes Ci5-Cia ketones have been investigated for hypocholesterolemic activity in rats. The position of the carbonyl group in the chain for maximum activity appears to be the 2 position. 2-Hexadecanone reduced serum cholesterol levels significantly without altering serum triglyceride levels. This drug was not estrogenic at effective doses which is in contrast to the cyclooctanones which possess this ...

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