Biochemistry (Washington) 2004-03-16

Quinones facilitate the self-assembly of the phosphorylated tubulin binding region of tau into fibrillar polymers.

Ismael Santa-María, Félix Hernández, Concepción Pérez Martín, Jesús Avila, Francisco J Moreno

Index: Biochemistry 43(10) , 2888-97, (2004)

Full Text: HTML

Abstract

The fragment of tau containing the first and third tubulin-binding motifs, involved in self-assembly of tau, was phosphorylated by protein kinase A (PKA). In the presence of hydroxynonenal (HNE) or in the presence of quinones such as juglone, 2,3-dimethoxy-5-methyl-1,4-benzoquinone (coenzyme Q(0) or DMM), or menadione, the polymerization of this phosphorylated tau fragment is catalyzed, whereas polymerization of the unmodified fragment takes place in a lesser extent. The quinones coenzyme Q(0) and menadione are found in every cell, including neural cells, and may interact with tau protein to facilitate its assembly into filamentous structures. These tau filaments, assembled in the presence of quinones, have a fibrillar morphology very similar to that of paired helical filaments present in the brains of patients with Alzheimer's disease.

Related Compounds

  • Ubiquinone Q0

Related Articles:

Cofactor Specificity of the Bifunctional Alcohol and Aldehyde Dehydrogenase (AdhE) in Wild-Type and Mutant Clostridium thermocellum and Thermoanaerobacterium saccharolyticum.

2015-08-01

[J. Bacteriol. 197 , 2610-9, (2015)]

Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death.

2012-02-01

[J. Bioenerg. Biomembr. 44(1) , 207-12, (2012)]

Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death.

2010-01-01

[PLoS ONE 5 , e11792, (2010)]

Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0.

2004-06-25

[J. Biol. Chem. 279 , 27278-27285, (2004)]

Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteins

2010-01-01

[Bioorg. Med. Chem. 18 , 3457-66, (2010)]

More Articles...