Bioorganic & Medicinal Chemistry Letters 1998-09-08

Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds.

A Nefzi, C Dooley, J M Ostresh, R A Houghten

Index: Bioorg. Med. Chem. Lett. 8(17) , 2273-8, (1998)

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Abstract

Modified dipeptides have been used successfully for the generation of a variety of small organic and heterocyclic combinatorial libraries, including linear urea, polyamine, hydantoin, thiohydantoin, cyclic urea, cyclic thiourea and bicyclic guanidine. The synthesis and screening results for a number of these libraries are described. The solid phase synthesis of heterocyclic compounds such as diazepine and thiomorpholinone are also described.