Polish journal of pharmacology and pharmacy 1980-01-01

3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.

B Witczuk, R A Khaunina, G Kupryszewski

Index: Pol. J. Pharmacol. Pharm. 32 , 187, (1980)

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Abstract

Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enantiomers has been determined. The R(+) enantiomer was found to be 4.2-9.2-fold as effective as the S(-) one and 1.4-1.9-fold as effective as the racemate.

Related Compounds

  • (R)-Baclofen (hyd...
  • (S)-Baclofen hydr...

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