Cardiology in Review 2009-01-01

Adenosine1 receptor antagonism: a new therapeutic approach for the treatment of decompensated heart failure.

Rena H Shah, William H Frishman

Index: Cardiol. Rev. 17(3) , 125-31, (2009)

Full Text: HTML

Abstract

Heart failure (HF) remains a major cause of morbidity and mortality, even with the use of standard treatments in patients with chronic HF and acute decompensated HF. Impaired renal function is an important prognostic indicator for adverse clinical outcomes. Elevated plasma levels of adenosine have been observed in HF patients and stimulation of adenosine1 receptors (A1R) in the kidney may be contributing to impaired renal function and treatment resistance. This observation has led to the development of A1R inhibitor drugs, both in oral and intravenous formulations, which in both animal and preliminary clinical trials have been shown to augment diuresis while preserving or improving renal function in HF patients. An extensive phase III clinical program using the A1R KW-3902 is now in progress in patients with symptomatic HF and renal dysfunction to evaluate the efficacy and safety of this treatment approach.

Related Compounds

  • KW 3902

Related Articles:

The effects of multiple doses of rolofylline on the single-dose pharmacokinetics of midazolam in healthy subjects.

2010-01-01

[Am. J. Ther. 17(1) , 53-60, (2010)]

The disconnect between phase II and phase III trials of drugs for heart failure.

2013-02-01

[Nat. Rev. Cardiol. 10(2) , 85-97, (2013)]

Design and rationale of the PROTECT study: a placebo-controlled randomized study of the selective A1 adenosine receptor antagonist rolofylline for patients hospitalized with acute decompensated heart failure and volume overload to assess treatment effect on congestion and renal function.

2010-01-01

[J. Card. Fail. 16(1) , 25-35, (2010)]

Adenosine A2 receptor activation attenuates afferent arteriolar autoregulation during adenosine receptor saturation in rats.

2007-10-01

[Hypertension 50(4) , 744-9, (2007)]

Haemodynamic effects of rolofylline in the treatment of patients with heart failure and impaired renal function.

2010-11-01

[Eur. J. Heart Fail. 12(11) , 1238-46, (2010)]

More Articles...