. beta. 1-Selective adrenoceptor antagonists. 2. 4-Ether-linked phenoxypropanolamines

…, RM Bradshaw, LC Blaber, DT Burden…

Index: Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 11 p. 1570 - 1576

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Citation Number: 22

Abstract

The use of @-adrenoceptor antagonists is now widely established in the treatment of essential hypertension. However, although cardioselective blockade appears to be of theoretical advantage, in practice the selectivity shown at low doses by the currently available agents is probably lost at the higher doses commonly used in patients.'P2 Thus, the ideal cardioselective P-blocker should show po- tent blockade of the &-receptors with no blockade of ...