Iminosugars: potential inhibitors of liver glycogen phosphorylase

…, M Kristiansen, J Breinholt, H Demuth, J Pawlas…

Index: Jakobsen, Palle; Lundbeck, Jane M; Kristiansen, Marit; Breinholt, Jens; Demuth, Helle; Pawlas, Jan; Torres Candela, Maria P; Andersen, Birgitte; Westergaard, Niels; Lundgren, Karsten; Asano, Naoki Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 733 - 744

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Citation Number: 90

Abstract

The first synthesis of the single isomers (3R, 4R, 5R);(3S, 4S, 5S);(3R, 4R, 5S) and (3S, 4S, 5R) of 5-hydroxymethylpiperidine-3, 4-diol from Arecolin is reported, including the synthesis of a series of N-substituted derivatives of the (3R, 4R, 5R)-isomer (Isofagomine). The inhibitory effect of these isomers as well as of a series of N-substituted derivatives of the (3R, 4R, 5R)-isomer and selected hydroxypiperidine analogues on liver glycogen ...