Journal of the American Chemical Society

Synthesis and biological evaluation of analogues of the antibiotic pantocin B

AE Sutton, J Clardy

Index: Sutton; Clardy Journal of the American Chemical Society, 2001 , vol. 123, # 41 p. 9935 - 9946

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Citation Number: 31

Abstract

Strains of the bacteria Erwinia herbicola produce antibiotics that effectively control E. amylovora, the bacterial pathogen responsible for the plant disease fire blight. Pantocin B was the first of these antibiotics to be characterized, and a flexible synthesis of various analogues is reported. Embedded in the “pseudo-tripeptide” backbone of pantocin B are a methylenediamine and a methyl sulfone, both unusual structural features in natural ...

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