New highly active taxoids from 9 beta-dihydrobaccatin-9,10-acetals. Part 5.
Yasuyuki Takeda, Kouichi Uoto, Michio Iwahana, Takeshi Jimbo, Motoko Nagata, Ryo Atsumi, Chiho Ono, Noriko Tanaka, Hirofumi Terasawa, Tsunehiko Soga
Index: Bioorg. Med. Chem. Lett. 14(12) , 3209-3215, (2004)
Full Text: HTML
Abstract
To improve the metabolic stability of 3, which exhibited both in vitro antitumor activity and in vivo efficacy by both iv and po administration, we designed and synthesized new taxane analogues. Most of the synthetic compounds maintained excellent antitumor activity and were scarcely metabolized by human liver microsomes. And some compounds exhibited potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration similarly to 3.
Related Compounds
Related Articles:
2012-01-01
[Molecules 17(12) , 14126-45, (2012)]
2008-04-18
[J. Org. Chem. 73(8) , 3094-102, (2008)]
Online mechanistic investigations of catalyzed reactions by electrospray ionization mass spectrometry: a tool to intercept transient species in solution. Santos LS.
[European J. Org. Chem. 2008(2) , 235-253, (2008)]
Synthesis of new thiazole-2,-4, and-5-yl-(amino) methylphosphonates and phosphinates: unprecedented cleavage of thiazole-2 derivatives under acidic conditions. Olszewski TK and Boduszek B.
[Tetrahedron 66(45) , 8661-866, (2010)]
The Morita-Baylis-Hillman Reaction: Advances and Contributions from Brazilian Chemistry. Santos MS, et al.
[Curr. Org. Synth. 12(6) , 830-852, (2015)]