The study of phosphoramidite as O-phosphitylation agent and its reactivity

SB Chen, YM Li, SZ Luo, G Zhao, B Tan…

Index: Chen, Shui-Bing; Li, Yan-Mei; Luo, Shi-Zhong; Zhao, Gang; Tan, Bo; Zhao, Yu-Fen Phosphorus, Sulfur and Silicon and Related Elements, 2000 , vol. 164, p. 277 - 291

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Citation Number: 9

Abstract

Abstract O-phosphorylated peptide and amino acid are important in living system. In this paper, Dialkyl-N, N-dialkyl phosphoramidites (DDPA) 3 were synthesized using two methods. The reaction of DDPA with the hydroxyl group of the corresponding amino acids in the presence of tetrazole, followed by oxidation, gave O-phosphoryl amino acid methyl esters in a good yield. A systematical study of the reactivity of DDPA was presented too.