Effective Methods for the Synthesis of N??Methyl β??Amino Acids from All Twenty Common α??Amino Acids Using 1, 3??Oxazolidin??5??ones and 1, 3??Oxazinan??6??ones

AB Hughes, BE Sleebs

Index: Hughes, Andrew B.; Sleebs, Brad E. Helvetica Chimica Acta, 2006 , vol. 89, # 11 p. 2611 - 2637

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Citation Number: 18

Abstract

Abstract N-Methyl β-amino acids are generally required for application in the synthesis of potentially bioactive modified peptides and other oligomers. Previous work highlighted the reductive cleavage of 1, 3-oxazolidin-5-ones to synthesise N-methyl α-amino acids. Starting from α-amino acids, two approaches were used to prepare the corresponding N-methyl β- amino acids. First, α-amino acids were converted to N-methyl α-amino acids by the so- ...