Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids

…, Y Kohara, E Imamiya, Y Sugiura, Y Inada…

Index: Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195

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Citation Number: 164

Abstract

(1H-tetrazol-byl) biphenyl-4-yllmethyll-1H-benzimidazole-7-carboxylic acid (26b, CV- 11974), inhibited the specific binding of [laI1AII to bovine adrenal cortical membrane with an ICw value of 1.1 X 10-7 M. The AII-induced contraction of rabbit aortic strips was antagonized by CV-11974 (ICs0 value, 3.0 X 1O-l0 M). Oral administration of CV-11974 to conscious normotensive rats at 1 mg/kg resulted in long-lasting inhibition of the AII- ...

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids