Synthesis of new aromatic retinoid analogs by low-valent titanium-induced reductive elimination

G Solladie, A Girardin, G Lang

Index: Solladie, Guy; Girardin, Andre; Lang, Gerard Journal of Organic Chemistry, 1989 , vol. 54, # 11 p. 2620 - 2628

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Citation Number: 29

Abstract

The low-valent titanium reductive elimination reaction, already applied to the stereospecific synthesis of vitamin A and 13-cis-retinol, was used to prepare several retinoic acid analogues in the all-trans configuration or in the 13-cis configuration. This highly stereospecific trans-diene formation allowed an improved synthesis of the title compounds without any purification of the intermediates before the final stage. all-trans-Retinoic acid ...